Following on from the supposed wonder pill that is Omega-3 rich fish oil, I wanted to give a mention to another wonder drug I’m on at the moment: Mirtazapine. It seems to take a lot of flak, but I’ve just been reading the small print on a new lot of just picked up from the pharmacy (I must be bored!), and found some rather interesting things:

“Mirtazapine is a potent antagonist of histamine (H1) receptors”

I had secretly been noticing, though not wanting to say it aloud for fear of putting a jinx on myself, that since I arrived back home at the beginning of August, I haven’t had a single stuffy or runny nose for the first time in the longest that I can remember! Now reading that factoid, that essentially I am taking a pretty strong antihistamine, I can understand why this is the first trip back that I haven’t felt like divorcing my nose because of the ubiquitous mould and mildew of my warmer clime homeland.

“Mirtapazine is a potent antagonist of 5-HT3 receptors”

When I looked up that receptor, it noted that antagonists are sometimes an anti-emetic. ie to stop nausea. It turns out that is also a ‘side effect’ of histamine antagonists too! At this point I must apologise to my fellow crew members last month when we were sailing: I was happily bumping up and down on the waves telling others (who were getting greener and greener) ‘ah you haven’t seen proper waves! I know I get sea sick, but I haven’t yet, so this must be nothing!’. It seems, that without knowing it, I was on some ‘potent’ anti-seasick tablets already!

Interestingly, according to Wikipedia, that same receptor is also antagonised by a drug called Memantine, which I recognise as the medication my grandfather is current trying in a bid to reverse his Alzheimer’s Disease symptoms. The jury is still out on the usefulness of that medication for that, but it’s interesting to think it is affecting the same thing that my mirtazapine also affects. Though I may be getting a bit ahead of myself to think I could also be staving off the Alzheimer’s that seems the inevitable ending of my family!

On the other hand, I was sorry to read:

“Mirtazapine is a potent antagonist of 5-HTreceptors”

as I just read that psychaedelic drugs like LSD are agonists at this receptor. Shucks! I was still waiting for that trip!

Now if I could just find something that will make me a bit less sweet to mosquitoes, I will be a very happy bunny!

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